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Wesley Chapel is in the Tampa Bay region of Florida. It's population as recorded in the 2010 Census was 44,092. Wesley Chapel is approximately 17 miles from Tampa (population 335,709) and around 17 miles from Brandon (population 103,483).

The median age for residents of Wesley Chapel is 35.2. Around 43.4% of Wesley Chapel households include school aged children and 17.8% of households include individuals aged 65 years or over. Census records indicate 74.9% of the Wesley Chapel population are White, 11.3% are Black or African American, .2% American Indian, 5.7% Asian and 3.5% are Two or more Races. Wesley Chapel has a significant Hispanic population. 20.1% (8,871) of Wesley Chapel residents are of Hispanic or Latino origin. Of these 8.24% are of Mexican origin, 43.03% Puerto Rican, 10.77% Cuban and 37.94% are of other Hispanic or Latino origin.

There are 17,764 housing units in Wesley Chapel. 2,019 (11.3%) of these were reported as vacant in the 2010 Census. Wesley Chapel is a tourist destination, 25.6% (517) of it's vacant housing units were classed as seasonal, recreational or for occasional use. There are 3,913 residential rental units in Wesley Chapel. 3,573 of them were occupied in 2010 providing a residential rental vacancy rate of 8.4%.